CODEINE PHOSPHATE

Name CODEINE PHOSPHATE

CAS 41444-62-6

Molecular Formula C18H24NO7P

Synonyma: CODEINE PHOSPHATE;CODEINEPHOSPHATE,USP;Codeine (phosphate hydrate);Codein phosphate hemihydrate;Codeine Phosphate (CII), USP;CODEINE PHOSPHATE HEMIHYDRATE;Codeine Phosphate CII (100 mg);N-METHYLNORCODEINE HEMIHYDRATE;CODEINIUM PHOSPHATE HEMIHYDRATE;Codeine·phosphoric acid·0.5hydrate

Category: Analgesic

Description

The use of this substance can be described as:
Codeine is used extensively to treat moderate to mild pain. Codeine is a weak μ agonist, but approximately 10% of an oral dose (30–60 mg) is metabolized to morphine, which contributes significantly to its analgesic effect. The plasma half-life of codeine after oral dose is 3.5 hours. The dose of codeine needed to produce analgesia after parenteral dose causes releases of histamine sufficient to produce hypotension, pruritus, and other allergic responses. Thus, administration of codeine by parenteral route is not recommended.

Available form	API powder
Indication	Mild to moderate pain management
Method of Analysis	USP BP
Status	Available
storage temp	2-8°C
solubility	Freely soluble in water, slightly soluble or very slightly soluble in ethanol
color	White or almost white
form	crystalline powder or small, colourless crystals

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