Metformin | 657-24-9

Chemical Name: Metformin

CAS No. 657-24-9

Summenformel: C4H11N5

Synonyma: Metformine;METFORMIN BASE;dimethylbiguanide;nndg;dmgg;melbin;la6023;Fluamine;gliguanid;flumamine

Category: Active pharmaceutical ingredient (API)

Description

ChEBI: Metformin is a member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1. It has a role as a hypoglycemic agent, a xenobiotic, an environmental contaminant and a geroprotector. It is functionally related to a biguanide. It is a conjugate base of a metformin(1+)ChEBI: Metformin is a member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1. It has a role as a hypoglycemic agent, a xenobiotic, an environmental contaminant and a geroprotector. It is functionally related to a biguanide. It is a conjugate base of a metformin(1+)

Additional information

Available form	API
Indication	Metformin (Glucophage) was used in Europe for many years before it was approved for use in the United States in 1995. Metformin is the only approved biguanide for the treatment of patients with NIDDM that are refractory to dietary management alone. Metformin does not affect insulin secretion but requires the presence of insulin to be effective. The exact mechanism of metformin’s action is not clear, but it does decrease hepatic glucose production and increase peripheral glucose uptake. When used as monotherapy, metformin rarely causes hypoglycemia.
Method of Analysis	USP-BP
Status	Available
storage temp	between 15 and 30 degrees C (59 and 86 degrees F)
form	Solid
solubility	At room temperature, it readily dissolves in water, with a solubility exceeding 300 mg/mL
color	White to Light Brown

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Metformin | 657-24-9